Research & science

DTU researcher co-designs AI proteins that protect mice from lethal snake venom

By Timothy Patrick Jenkins (DTU Bioengineering) and David Baker (University of Washington)
RFdiffusion

Built and shared by Timothy Patrick Jenkins (DTU Bioengineering) and David Baker (University of Washington), not by me. Summarised from the public sources below. Check them before you rely on a number.

Who
Timothy Patrick Jenkins (DTU Bioengineering) and David Baker (University of Washington)
Category
Research & science
Source
Web
Dates
Published 15 Jan 2025 · Found 17 Oct 2026

Timothy Patrick Jenkins of DTU and David Baker's lab at the University of Washington used deep learning to design new proteins that bind and neutralise cobra toxins. The designed proteins protected mice from lethal doses, which could lead to cheaper and safer antivenoms.

What they built

The researchers used RFdiffusion and other deep learning tools to design proteins from scratch that bind three-finger toxins (short- and long-chain alpha-neurotoxins and cytotoxins) from elapid snakes. Only a small number of designs had to be tested in the lab, and the best ones showed high stability and binding that closely matched the computational models.

The result

80-100% survival in mice depending on dose, toxin and protein. In rescue tests, binders given 15 minutes after the toxin gave 100% protection. Published in Nature.

Sources

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